I don't know how many guys are out there that hunt with handguns in the semi auto calibers currently legal for deer but IDNR is proposing changing the caliber list to "Centerfire handguns must be .357 caliber or larger, use straight-walled cartridges with a case that is at least 1.16 inches long without the bullet" which would rule out all the semi auto pistol cartridges (including 10MM) except .50AE
http://www.iowadnr.gov/nrc/11mar/24.pdf
http://www.iowadnr.gov/nrc/11mar/24.pdf