bigbuckhunter88
PMA Member
Wait till all the city folk start calling 911 saying they have "zombie deer" eating in their flowerbeds/gardens/lawns. Probably has already happened since the article was posted
Wi transplant
PMA Member
Seems to be lots of speculation in that article. Just my 2 cents worth if its been here for 50 yrs and no one has got it yet the odds are low! Not saying it cant happen but no need to cause undo panic!
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Sent from my RS501 using Tapatalk
loneranger
Well-Known Member
Once this gets into all main stream media watch out. Calls for extermination of wild deer,Elk,Moose. And the Farm Bureau and Insurance Companies will join the chorus.
sirrloin
Active Member
Prions/proteins are adaptable and able to mutate to survive in many environments. Usually evolutionary jumps aren't slow over time but abrupt. We see this all the time with bacteria when they become more resistant and immune to antibiotics. All it takes is for something to make that initial jump. If it did there would be a legitimate cause to panic. Living and working in close quarters is probably the last thing you'd want for something prion based. That being said there's been nothing to suggest that it's going in our direction. Possible yes...likely...not very.
loneranger
Well-Known Member
Thought prions were in brain spinal. Course saliva too. Muscles??
I have A question on this. With the cases of CJD, don't care which type CJD, vCJD or sCJD, are those patients quarantined? If in fact the human version can transmit through saliva and fluids as the deer version is believed to at food and mineral stations wouldn't it make sense?? Also, wouldn't the person's house and anything he/she sneezes on have the prions on it for a long time?
jkratz5
Well-Known Member
I like the term Zombie deer, typical media overhype and the reason why no one believes the garbage they post. A simple education on the topic would be plenty and what should be done if you see these signs
As for transmission, anything is possible and like stated above mutations happen to keep species living. That being said with the data presented to date I think all the speculation presented is pretty far reaching
As for transmission, anything is possible and like stated above mutations happen to keep species living. That being said with the data presented to date I think all the speculation presented is pretty far reaching
flounder9
Member
science laboratory studies have shown that cwd transmission to humans will NOT look like nvcjd or what they call now as vcjd.
all science has shown to date that cwd transmission to humans will look like sporadic cjd, 85%+ of all human tse prion disease.
cwd in humans has been misdiagnosed for decades, as sporadic cjd.
***Furthermore, the form of human PrPres produced in this in vitro assay when seeded with CWD, resembles that found in the most common human prion disease, namely sCJD of the MM1 subtype.
snip...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884726/
*** now, let’s see what the authors said about this casual link, personal communications years ago, and then the latest on the zoonotic potential from CWD to humans from the TOKYO PRION 2016 CONFERENCE.
see where it is stated NO STRONG evidence. so, does this mean there IS casual evidence ???? “Our conclusion stating that we found no strong evidence of CWD transmission to humans”
From: TSS (216-119-163-189.ipset45.wt.net)
Subject: CWD aka MAD DEER/ELK TO HUMANS ???
Date: September 30, 2002 at 7:06 am PST
From: "Belay, Ermias"
To: Cc: "Race, Richard (NIH)" ; ; "Belay, Ermias"
Sent: Monday, September 30, 2002 9:22 AM
Subject: RE: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS
Dear Sir/Madam,
In the Archives of Neurology you quoted (the abstract of which was attached to your email), we did not say CWD in humans will present like variant CJD.. That assumption would be wrong. I encourage you to read the whole article and call me if you have questions or need more clarification (phone: 404-639-3091). Also, we do not claim that "no-one has ever been infected with prion disease from eating venison." Our conclusion stating that we found no strong evidence of CWD transmission to humans in the article you quoted or in any other forum is limited to the patients we investigated.
Ermias Belay, M.D. Centers for Disease Control and Prevention
-----Original Message-----
From: Sent: Sunday, September 29, 2002 10:15 AM
To: rr26k@nih.gov; rrace@niaid.nih.gov; ebb8@CDC.GOV
Subject: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS
Sunday, November 10, 2002 6:26 PM .......snip........end..............TSS
Thursday, April 03, 2008
A prion disease of cervids: Chronic wasting disease 2008 1: Vet Res. 2008 Apr 3;39(4):41 A prion disease of cervids: Chronic wasting disease Sigurdson CJ.
snip...
*** twenty-seven CJD patients who regularly consumed venison were reported to the Surveillance Center***,
snip... full text ;
http://chronic-wasting-disease.blogspot.com/2008/04/prion-disease-of-cervids-chronic.html
> However, to date, no CWD infections have been reported in people.
key word here is 'reported'. science has shown that CWD in humans will look like sporadic CJD. SO, how can one assume that CWD has not already transmitted to humans? they can't, and it's as simple as that. from all recorded science to date, CWD has already transmitted to humans, and it's being misdiagnosed as sporadic CJD. ...terry
*** LOOKING FOR CWD IN HUMANS AS nvCJD or as an ATYPICAL CJD, LOOKING IN ALL THE WRONG PLACES $$$ ***
*** These results would seem to suggest that CWD does indeed have zoonotic potential, at least as judged by the compatibility of CWD prions and their human PrPC target. Furthermore, extrapolation from this simple in vitro assay suggests that if zoonotic CWD occurred, it would most likely effect those of the PRNP codon 129-MM genotype and that the PrPres type would be similar to that found in the most common subtype of sCJD (MM1).***
http://www.tandfonline.com/doi/full/10.4161/pri.28124?src=recsys
http://www.tandfonline.com/doi/pdf/10.4161/pri.28124?needAccess=true
https://wwwnc.cdc.gov/eid/article/20/1/13-0858_article
terry
flounder9
Member
Prion Infectivity in Fat of Deer with Chronic Wasting Disease▿
Brent Race#, Kimberly Meade-White#, Richard Race and Bruce Chesebro* + Author Affiliations
In mice, prion infectivity was recently detected in fat. Since ruminant fat is consumed by humans and fed to animals, we determined infectivity titers in fat from two CWD-infected deer. Deer fat devoid of muscle contained low levels of CWD infectivity and might be a risk factor for prion infection of other species.
http://jvi.asm.org/content/83/18/9608.full
Prions in Skeletal Muscles of Deer with Chronic Wasting Disease
Here bioassays in transgenic mice expressing cervid prion protein revealed the presence of infectious prions in skeletal muscles of CWD-infected deer, demonstrating that humans consuming or handling meat from CWD-infected deer are at risk to prion exposure.
http://science.sciencemag.org/content/311/5764/1117.long
terry
flounder9
Member
officials keep saying NO. bbbut, i have my doubts, and i have come to find with these pesky tse prions, never say never...
The occurrence of the disease in a patient who had contact with cases of familial C.J.D., but was not genetically related, has been described in Chile (Galvez et al., 1980) and in France (Brown et al., 1979b). In Chile the patient was related by marriage, but with no consanguinity, and had social contact with subsequently affected family members for 13 years before developing the disease. The contact case in France also married into a family in which C.J.D. was prevalent and had close contact with an affected member. In neither instance did the spouse of the non-familial case have the disease. The case described in this report was similarly related to affected family members and social contact had occurred for 20 years prior to developing C.J.D. If contact transmission had occurred, the minimum transmission period would be 11 years. Contact between sporadic cases has not been described and it is remarkable that possible contact transmissions have all been with familial cases. No method of transmission by casual social contact has been suggested.
***The occurrence of contact cases raises the possibility that transmission in families may be effected by an unusually virulent strain of the agent.
snip...see full text here;
http://web.archive.org/web/20050425210551/http://www.bseinquiry.gov.uk/files/mb/m26/tab01.pdf
http://transmissiblespongiformencep...014/01/vpspr-sgss-sffi-tse-iatrogenic-by.html
Thursday, March 8, 2018
Familial human prion diseases associated with prion protein mutations Y226X and G131V are transmissible to transgenic mice expressing human prion protein
http://familialcjdtseprion.blogspot.com/2018/03/familial-human-prion-diseases.html
SUNDAY, FEBRUARY 10, 2019
The prion-like propagation hypothesis in Alzheimer's and Parkinson's disease
https://betaamyloidcjd.blogspot.com/2019/02/the-prion-like-propagation-hypothesis.html
terry
Hardwood11
It is going to be a good fall!
Terry- put a scrambler/decoder on your computer that make your comments readable.
Has there been an increase in prevalence of sporadic CJD in North America over the last 50 years? It seems to me if CWD to humans is occurring (in sporadic form not vCJD as “originally” thought), we would be seeing a relatively obvious increase in the number of sporadic CJD cases occurring every year. Is this happening ?
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Read the late sentence of this I found from the National Institute of Health.
creased. These findings are consistent with other studies that indicate a relative excess of cases among females [33], [35]–[38] but a higher incidence of CJD among the male population [35], [39]. The CJD incidence rates varied regionally, with the highest rate in the Northeast region and the lowest rates in the South and West regions. The low rate in the West is of particular interest due to the longstanding presence of chronic wasting disease (CWD) among cervids in parts of the region, particularly in Colorado and Wyoming.
flounder9
Member
Chronic Wasting Disease CWD TSE Prion aka mad deer disease zoonosis
We hypothesize that:
(1) The classic CWD prion strain can infect humans at low levels in the brain and peripheral lymphoid tissues;
(2) The cervid-to-human transmission barrier is dependent on the cervid prion strain and influenced by the host (human) prion protein (PrP) primary sequence;
(3) Reliable essays can be established to detect CWD infection in humans; and
(4) CWD transmission to humans has already occurred. We will test these hypotheses in 4 Aims using transgenic (Tg) mouse models and complementary in vitro approaches.
http://grantome.com/grant/NIH/R01-NS088604-04
ZOONOTIC CHRONIC WASTING DISEASE CWD TSE PRION UPDATE
here is the latest;
PRION 2018 CONFERENCE
Oral transmission of CWD into Cynomolgus macaques: signs of atypical disease, prion conversion and infectivity in macaques and bio-assayed transgenic mice
Taken together, there is strong evidence of transmissibility of CWD orally into macaques and from macaque tissues into transgenic mouse models, although with an incomplete attack rate.
The clinical and pathological presentation in macaques was mostly atypical, with a strong emphasis on spinal cord pathology.
Our ongoing studies will show whether the transmission of CWD into macaques and passage in transgenic mice represents a form of non-adaptive prion amplification, and whether macaque-adapted prions have the potential to infect mice expressing human PrP.
The notion that CWD can be transmitted orally into both new-world and old-world non-human primates asks for a careful reevaluation of the zoonotic risk of CWD..
***> The notion that CWD can be transmitted orally into both new-world and old-world non-human primates asks for a careful reevaluation of the zoonotic risk of CWD. <***
https://prion2018.org/
READING OVER THE PRION 2018 ABSTRACT BOOK, LOOKS LIKE THEY FOUND THAT from this study ;
P190 Human prion disease mortality rates by occurrence of chronic wasting disease in freeranging cervids, United States
Abrams JY (1), Maddox RA (1), Schonberger LB (1), Person MK (1), Appleby BS (2), Belay ED (1) (1) Centers for Disease Control and Prevention (CDC), National Center for Emerging and Zoonotic Infectious Diseases, Atlanta, GA, USA (2) Case Western Reserve University, National Prion Disease Pathology Surveillance Center (NPDPSC), Cleveland, OH, USA..
SEEMS THAT THEY FOUND Highly endemic states had a higher rate of prion disease mortality compared to non-CWD
states.
AND ANOTHER STUDY;
P172 Peripheral Neuropathy in Patients with Prion Disease
Wang H(1), Cohen M(1), Appleby BS(1,2) (1) University Hospitals Cleveland Medical Center, Cleveland, Ohio (2) National Prion Disease Pathology Surveillance Center, Cleveland, Ohio..
IN THIS STUDY, THERE WERE autopsy-proven prion cases from the National Prion Disease Pathology Surveillance Center that were diagnosed between September 2016 to March 2017,
AND
included 104 patients. SEEMS THEY FOUND THAT The most common sCJD subtype was MV1-2 (30%), followed by MM1-2 (20%),
AND
THAT The Majority of cases were male (60%), AND half of them had exposure to wild game.
snip...
see more on Prion 2017 Macaque study from Prion 2017 Conference and other updated science on cwd tse prion zoonosis below...terry
https://prion2018.org/wp-content/uploads/2018/05/program.pdf
https://prion2018.org/
THURSDAY, OCTOBER 04, 2018
Cervid to human prion transmission 5R01NS088604-04 Update
http://grantome.com/grant/NIH/R01-NS088604-04
http://chronic-wasting-disease.blogspot.com/2018/10/cervid-to-human-prion-transmission.html
flounder9
Member
we use to call that crypto gear in the Navy, i use to have to work on that...LOL!
https://www.cryptomuseum.com/crypto/usa/kw7/index.htm
flounder9
Member
to all the non believer ted nugent science fans, eat up, it's all fake news...LOL! bon appetit...
bigbuckhunter88
PMA Member
Don't think anyone is a none believer but would love for someone to show how many deer it kills and how killing them all is the answer. And no I don't need links to 47 useless articles that I don't have the time nor want to read.